J Asian Nat Prod Res. 2009; 11(3): 274-80Jiao XZ, Wang LP, Xiao Q, Xie P, Liang XTA new approach for the synthesis of the (+)-conagenin has been achieved based on Evans asymmetry syn-aldol reaction and the self-regeneration of stereocenters strategy.

J Nat Prod. 2009 Apr 29; Wang HB, Gu WF, Chu WJ, Zhang S, Tang XC, Qin GWFour new "cage-like" monoterpene glucosides (1-4) were isolated from Paeonia lactiflora. The structures of these compounds were established by spectroscopic methods, mainly 1D and 2D NMR, and mass spectrometric analysis. Compound 4 exhibited moderate cell-protective activity against hydrogen peroxide-induced PC12 cell damage.

J Asian Nat Prod Res. 2009; 11(3): 281-7Xue P, Wang LP, Jiao XZ, Jiang YJ, Xiao Q, Luo ZG, Xie P, Liang XT( - )-Talaumidin (1) and ( - )-galbelgin (2) have been synthesized via 4-pentenoic acid as a starting material with the overall yield of about 17.8 and 16.9%, respectively. The key steps include Evans asymmetry anti-aldol reaction, TBS protection, hydroboration, oxidation, Friedel-Crafts arylation, etc.

Bioorg Med Chem Lett. 2009 Mar 28; Duan H, Zheng J, Lai Q, Liu Z, Tian G, Wang Z, Li J, Shen JIn our efforts to minimize the side effects associated with low selectivity against the other PDE isozymes, a novel class of 2-phenylquinazolin-4(3H)-one derivatives were designed and prepared as potent PDE5 inhibitors with high selectivity against PDE6. The syntheses and SAR studies of such molecules were reported.

Magn Reson Chem. 2009 Apr 28; Feng J, Zhao WFour new oligosaccharides (1-4), one new pregnane glycoside (5), and one new cardiac glycoside (6) were isolated from the roots of Periploca forrestii Schltr. (Asclepiadaceae), a traditional Chinese medicine used for the treatment of rheumatoid arthritis and wounds. Their structures were characterized on the basis of extensive analysis of NMR ((1)H, (13)C NMR, (1)H-(1)H COSY, HSQC, HMBC, TOCSY and ROESY) spectra. Copyright (c) 2009 John Wiley & Sons, Ltd.