J Comb Chem. 2009 Jul 31; Jiang M, Li T, Meng L, Yang C, Xie Y, Ding JC-5 arylated 2/9-substituted pyrimido[5,4-b]indolizines were synthesized via palladium-catalyzed direct arylation. A variety of substituents on both pyrimido[5,4-b]indolizines and aryl/heteroaryl bromides are tolerated, providing rapid access to substituted pyrimido[5,4-b]indolizines in good to excellent yields.

Zhongguo Zhong Yao Za Zhi. 2009 May; 34(10): 1225-7Ouyang F, Liu Y, Xiao H, Yu H, Wang N, Yao XOBJECTIVE: To study the chemical constitutents of the 60% ethanol extract of the stems of Sambucus williamsii. METHOD: Compounds were isolated and purified by Diaion D101, silica gel,Sephadex LH-20, ODS column chromatography and preparative HPLC. Their structures were identified by spectroscopic methods. RESULT: Seven lignans were isolated and identified as erythro-guaiacylglycerol-beta-O-4'-sinapyl ether (1), 1-( 4'-hydroxy-3'-methoxyphenyl) -2- [4"-( 3-hydroxypropyl) -2", 6"-dimethoxyphenoxy] propane-1,3-diol (2), isolariciresinol (3), burselignan (4), lyoniresinol (5), 5-methoxy-isolariciresinol (6), cycloolivil (7). CONCLUSION: All these compounds were obtained from this genus for the first time.

Zhongguo Zhong Yao Za Zhi. 2009 May; 34(10): 1216-9Li X, Feng Z, Huo W, Li Y, Wang B, Zhu SOBJECTIVE: To establish a method to evaluate the in vitro release of Zhike Pingchuan sustained-release tablets. METHOD: The ephedrine, pseudoephedrine, scopolamine were chosen as marker components components, and the chromatographic conditions were chosen according to the separation of baseline and theoretical plate number for determining the marker in vitro release of Zhike Pingchuan sustained-release tablets; through the dissolution curves of the three active components, the release behavior was judged as well-balanced release or not. RESULT: Compared with conventional tablets, the Zhike Pingchuan sustained-release tablets had a well-balanced behavior in 10 h. CONCLUSION: The maker components of Zhike Pingchuan sustained-release tablets and two chromatographic conditions, which were used to determine the dissolution of the sustained-release tablets, could be chosen as evaluation methods for the in vitro release of Zhike Pingchuan sustained-release tablets.

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 May; 29(5): 422-4Shi YT, Si CF, Liu BOBJECTIVE: To study the kinetogenic effects of serum containing Semen Arecae, Dandelion, Semen raphaniand Atractylodes macrocephala on the colonic smooth muscle cells of rats. METHODS: Serum containing Chinese materia medicas was made according to standard methods. Smooth muscle cells were isolated from the muscle layers of Wistar rat's colon, referred to modified Bitar's method. The contractile response of colonic smooth muscle cells to serum containing Chinese materia medicas (10%, 50%, 100% concentration) and other medicines (blank and 1 x 10(-3) mol/L acetylcholine) were separately observed. The contractility was presented by the decrease of the cell length between the drug groups and the control. RESULTS: Serum containing each Chinese materia medica can make dose-dependent contraction at different concentrations (P < 0.05), but the strongest effect of each serum had no significant difference (P > 0.05). CONCLUSION: Serum containing Semen Arecae, Dandelion, Semen raphani and Atractylodes macrocephala can make notable contraction on colonic smooth muscle cells in rats.