Investigation of Changes in NO Content during Long-Term Sensitization in Edible Snail Using EPR-Spectroscopy: Effects of Antibodies to Calcium-Binding Protein S-100.

Bull Exp Biol Med. 2008 Dec; 146(6): 675-679Gainutdinov KL, Andrianov VV, Gainutdinova TK, Muranova LN, Obynochny AA, Timoshenko AK, Shtark MB, Epstein OI, Yurtaeva SV, Jafarova GGEPR-spectroscopy experiments (electron paramagnetic resonance) demonstrated a decrease in NO production in the nervous system and heart of edible snail Helix lucorum after formation of long-term sensitization, a neurobiological model of anxiety and depression. The protective effect of antibodies to Ca(2+)-binding protein S-100 in dilution of 10(-12)on the formation of long-term sensitization was accompanied by partial recovery of NO synthesis in the nervous system and heart. These findings indicate that the imbalance in Ca(2+)-binding protein S-100 can lead to inhibition or modulation of some processes during plastic reorganization in the body and especially during pathological processes.