Experimental study of ultralow-dose antibodies to cyclophosphamide on cyclophosphamide myelotoxicity.

Bull Exp Biol Med. 2009 Mar; 147(3): 323-7Epstein OI, Dygai AM, Sergeeva SA, Zhdanov VV, Khrichkova TY, Stavrova LA, Zyuz'kov GN, Udut EV, Simanina EVThe possibility of using ultralow-dose cyclophosphamide for reducing the myelotoxicity of cyclophosphamide, injected in the maximum permissible dose, was studied in mice. Combined treatment by the cytostatic and its ultralow-dose preparation led to a lesser suppression of the erythroid, lymphocytic, and particularly granulocytic hemopoiesis stems. This effect is explained by stimulation of the secretory activity of hemopoiesis-inducing microenvironment and hence, of the functional activity of granulocytopoiesis under the effect of ultralow-dose cyclophosphamide.