Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones.

Org Lett. 2009 Jun 1; Mei K, Jin M, Zhang S, Li P, Liu W, Chen X, Xue F, Duan W, Wang WA highly enantioselective conjugate addition of nitroalkanes to enones has been developed. The process is efficiently catalyzed by a simple chiral cyclohexanediamine-derived primary amine thiourea with a broad substrate scope.