[Study on vitro release and transdermal behaviors of Yulian cataplasm]

Zhongguo Zhong Yao Za Zhi. 2009 Apr; 34(8): 969-72Du M, Liu S, Li M, Jin R, Kang C, Li JOBJECTIVE: To investigate the regularity of Yulian Cataplasm in vitro release and transdermal behaviors. METHOD: Improved Franz diffusion devices was used with four index ingredients as evodiamine, rutaecarpine, palmatine and berberine that were determined by HPLC in one mobile phase. RESULT: The release rates of evodiamine, rutaecarpine, palmatine and berberine were 0.0239, 0.0156, 0.0725, 0.8191 mg x cm(-2) x h(-1/2), respectivley. The transdermal rates of evodiamine, rutaecarpine, palmatine and berberine were 1.256, 1.0302, 2.8029, 20.919 microg x cm(-2) x h(-1), respectively. CONCLUSION: The releasing process of all index is in accordance with Higuchi equation and the transdermal proccess is in accordance with zero-level equation.